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The negative impacts of climate change on agriculture could erode gains made toward gender equality in Ghana. Much of the literature on gender dimensions of climate change adaptation has focused on assessing differences in coping and adaptation practices of smallholder farmers. Mostly overlooked is whether gender influences influenced perception of effectiveness of adaptation practices and preferences for institutional support for future adaptation. Using key informant interviews, household surveys, and focus group discussions, we address these gaps by exploring coping and adaptation measures adopted by heads of farm households to counter climate change impacts on their livelihood activities and household well-being in the Guinea Savanna agroecological zone in Ghana. Additionally, we assessed the preferred institutional adaptation support of heads of farm households in adapting to future projected impacts. We find that female heads of farm households relied mainly on borrowed money from village savings and loans group as a coping measure; male heads of farm households depended primarily on sales of livestock. Varying planting and harvesting dates, crop diversification, and use of improved crop varieties were the major adaptation strategies adopted by farmers. We argue that provision of dams and/or dugouts, postharvest processing facilities, adaptation capacity-building resources, and improved access to markets and credit could enhance the adaptive capacity of male and female heads of farm households to mitigate projected climate change impacts on their livelihood activities and household well-being.